Miller Fisher Syndrome

A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)

Also Known As:

Fisher Syndrome; Syndrome, Miller Fisher; Guillain-Barre Syndrome, Miller Fisher Variant; Miller Fisher Variant of Guillain Barre Syndrome; Miller-Fisher Syndrome; Syndrome, Fisher; Syndrome, Miller-Fisher; Guillain Barre Syndrome, Miller Fisher Variant; Ophthalmoplegia, Ataxia and Areflexia Syndrome

Nervous System Diseases: 14737
- Demyelinating Diseases: 9340
  - Polyradiculoneuropathy: 335
    - Guillain-Barre Syndrome: 3789
      - Miller Fisher Syndrome: 444
- Central Nervous System Diseases: 4371
  - Brain Diseases: 16141
    - Cerebellar Diseases: 647
      - Miller Fisher Syndrome: 444
- Neuromuscular Diseases: 2048
  - Peripheral Nervous System Diseases: 11768
    - Polyneuropathies: 5219
      - Polyradiculoneuropathy: 335
        Guillain-Barre Syndrome: 3789
        Miller Fisher Syndrome: 444
- Autoimmune Diseases of the Nervous System: 1576
  - Polyradiculoneuropathy: 335
    - Guillain-Barre Syndrome: 3789
      - Miller Fisher Syndrome: 444
- Cranial Nerve Diseases: 564
  - Ocular Motility Disorders: 523
    - Miller Fisher Syndrome: 444
Eye Diseases: 3620
- Ocular Motility Disorders: 523
  - Miller Fisher Syndrome: 444
Immune System Diseases: 4430
- Autoimmune Diseases: 35458
  - Autoimmune Diseases of the Nervous System: 1576
    - Polyradiculoneuropathy: 335
      - Guillain-Barre Syndrome: 3789
        Miller Fisher Syndrome: 444

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Disease

Drug/Important Bio-Agent (IBA)